HCID 11409728, compound → HCID 11407650, compound

HRID 895830Notes

Reaction equation

HRID 895830 reaction equation
C([O:8][C:9]1[CH:35]=[CH:34][C:12]([N:13]([CH2:24][CH2:25][O:26][Si:27]([C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:29])[CH3:28])[CH2:14][CH2:15][O:16][Si:17]([C:20]([CH3:23])([CH3:22])[CH3:21])([CH3:19])[CH3:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>C1COCC1.[Pd]>[Si:17]([O:16][CH2:15][CH2:14][N:13]([C:12]1[CH:34]=[CH:35][C:9]([OH:8])=[CH:10][CH:11]=1)[CH2:24][CH2:25][O:26][Si:27]([C:30]([CH3:31])([CH3:32])[CH3:33])([CH3:29])[CH3:28])([C:20]([CH3:21])([CH3:22])[CH3:23])([CH3:19])[CH3:18]

Participants

4

Reactant 1

HCID 11409728HCID 11409728, compound

Product 1

HCID 11407650HCID 11407650, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

The benzyl ether 3A (11.4 g, 22.1 mmol) was dissolved in THF, Pd/C catalyst (1.6 g) was added and the suspension stirred overnight under H2 atmosphere. The catalyst was filtered off, the solvent evaporated to afford 4A (9.4 g, 100%) as an oil.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-93bbbea49209493bba94139bf2d12d01
Source dataset
uspto-grants-2005_07
Patent number
US06916949B2

Reaction notes

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