Trifluoroacetic acid → HCID 22382056, compound

A mixture containing 1,6-dimethyl-4-(trifluoromethyl)-2-pyridone (2.1 g, 10.98 mmol), trifluoroacetic acid (18 mL) and trifluoroacetic anhydride (3.5 mL) was refluxed for 5 min. Then, NIS (3.15 g, 14 mmol) was added and the reaction mixture was stirred for 15 h. The reaction mixture was cooled to room temperature and the solvent was removed under vacuum. The residue was diluted with ethyl acetate (100 mL), was washed with saturated sodium bicarbonate solution (2×100 mL) and brine solution (100 mL) and was dried over anhydrous magnesium sulfate. Filtration of the drying agent and concentration gave a crude product, which was purified by silica gel chromatography on a Biotage (40 m) column to afford 2.15 g (62% yield) of 1,6-dimethyl-3-iodo-4-(trifluoromethyl)-2-pyridone as an amorphous white solid. EL-HRMS m/e calcd for C8H7F3INO (M+) 316.9524. found 316.9527. c) Preparation of N-[(1,1-dimethylethoxyl)carbonyl]-4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester

1. temperaturewas refluxed for 5 min
2. customthe solvent was removed under vacuum
3. additionThe residue was diluted with ethyl acetate (100 mL)
4. washwas washed with saturated sodium bicarbonate solution (2×100 mL) and brine solution (100 mL)
5. dry with materialwas dried over anhydrous magnesium sulfate
6. filtrationFiltration of the drying agent and concentration
7. customgave a crude product, which
8. customwas purified by silica gel chromatography on a Biotage (40 m) column

ORD record

ord-9730ef77c4de4a71b4370751bd83c860

Source dataset

uspto-grants-2005_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06916933B2