反应详情

(5-Bromo-2-methoxy-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanone (50 mg; 0.12 mmol), 2-tributylstannylpyridine (88 mg; 0.26 mmol) and PdCl2(PPh3)2 (25 mg; 0.035 mmol) are dissolved in xylene (2 ml) and refluxed for 4.5 hours. The reaction mixture is diluted with TBME and filtered through a bed of SiO2. The resulting solid is dissolved in ether, crystallized by adding hexanes and yields the title compound as yellowish crystals (20 mg; 40%).

1. temperaturerefluxed for 4.5 hours
2. filtrationfiltered through a bed of SiO2
3. dissolutionThe resulting solid is dissolved in ether
4. customcrystallized
5. additionby adding hexanes