Ammonium Chloride → 6-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one

HRID 896206Notes

Reaction equation

HRID 896206 reaction equation
[CH2:1]([N:3]1[C:7]2[C:8]([F:15])=[CH:9][C:10]([N+:12]([O-])=O)=[CH:11][C:6]=2[O:5][C:4]1=[O:16])[CH3:2].[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:12][C:10]1[CH:9]=[C:8]([F:15])[C:7]2[N:3]([CH2:1][CH3:2])[C:4](=[O:16])[O:5][C:6]=2[CH:11]=1

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 45095618HCID 45095618, compound

Product 1

HCID 684905716-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Prepared from 3-ethyl-4-fluoro-6-nitro-1,3-benzoxazol-2(3H)-one (Step 1, 1.05 g, 4.90 mmol), ammonium chloride (2.62 g, 49 mmol) and iron powder (1.09 g, 19.6 mmol) in ethanol (30 ml) and water (15 ml) according to the method of EXAMPLE 86, Step 7 (0.95 g, 99%).

Sources & evidence

ORD record
ord-749f4ec2a8264e54816f1e2671b08f23
Source dataset
uspto-grants-2005_07
Patent number
US06919329B2

Reaction notes

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