反应详情

15 g of 2-tert-butyl-4-piperazin-1-yl-6-propyl-pyrimidine (57.2 mmol), 9 g of 1-bromo-3-chloropropane (57.2 mmol), 8.7 g of triethylamine (86.2 mmol) in 200 ml of acetonitrile were heated to reflux for 3 h. The precipitate was filtered off and the remaining filtrate evaporated to dryness. The thus obtained crude product was purified by chromatography on silica gel with dichloromethane/methanol (0-5%). Yield: 6 g (31%).

1. temperatureto reflux for 3 h
2. filtrationThe precipitate was filtered off
3. customthe remaining filtrate evaporated to dryness
4. customThe thus obtained crude product
5. customwas purified by chromatography on silica gel with dichloromethane/methanol (0-5%)