4-(Benzyloxy)-5-methoxy-2-nitrobenzonitrile → HCID 22349623, compound

HRID 896250Notes

Reaction equation

HRID 896250 reaction equation
[N+:1]([C:4]1[CH:11]=[C:10]([O:12]CC2C=CC=CC=2)[C:9]([O:20][CH3:21])=[CH:8][C:5]=1[C:6]#[N:7])([O-:3])=[O:2]>FC(F)(F)C(O)=O>[N+:1]([C:4]1[CH:11]=[C:10]([OH:12])[C:9]([O:20][CH3:21])=[CH:8][C:5]=1[C:6]#[N:7])([O-:3])=[O:2]

Participants

3

Reactant 1

HCID 116736184-(Benzyloxy)-5-methoxy-2-nitrobenzonitrile

Product 1

HCID 22349623HCID 22349623, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2-nitro-4-benzyloxy-5-methoxybenzonitrile (3 g, 10.6 mmol) was treated with trifluoroacetic acid (30 ml) at reflux for 0.5 hour. The solvent was evaporated, the residue triturated with ether to give a yellow solid of title compound (1.27 g, 62%).

Workup

  1. temperatureat reflux for 0.5 hour
  2. customThe solvent was evaporated
  3. customthe residue triturated with ether

Sources & evidence

ORD record
ord-5faa2a5845174eb78fa8dbce174e4cf7
Source dataset
uspto-grants-2005_07
Patent number
US06919338B2

Reaction notes

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