Sodium → HCID 11516899, compound

HRID 896262Notes

Reaction equation

HRID 896262 reaction equation
C[O:2][C:3](=[O:30])[CH2:4][C:5]1[S:9][C:8]([NH:10][C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:7][CH:6]=1.[Na]>C1COCC1.C(O)C>[C:11]([NH:10][C:8]1[S:9][C:5]([CH2:4][C:3]([OH:30])=[O:2])=[CH:6][N:7]=1)([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 5360545SodiumHCID 11676009HCID 11676009, compound

Product 1

HCID 11516899HCID 11516899, compoundYield 102%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Methyl(2-tritylamino-1,3-thiazole-5-yl)acetate (2 g, 4.8 mmol) in THF (10 ml) and ethanol (10 ml) was reacted with sodium hydroxyde (1N, 7.2 ml, 7.2 mmol) at room temperature for 1.5 hour. The solvent was evaporated, HCl (6N) was added, the solid recovered by filtration to give title compound (1.96 g).

Workup

  1. customThe solvent was evaporated
  2. additionHCl (6N) was added
  3. filtrationthe solid recovered by filtration

Sources & evidence

ORD record
ord-330d564e82cb4e40b83e9f036d58d31d
Source dataset
uspto-grants-2005_07
Patent number
US06919338B2

Reaction notes

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