Sodium → HCID 22349636, compound

HRID 896266Notes

Reaction equation

HRID 896266 reaction equation
C[O:2][C:3](=[O:19])[C:4]([C:6]1[S:10][C:9]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[N:8][CH:7]=1)=[O:5].[Na]>C(O)C>[C:15]([O:14][C:12]([NH:11][C:9]1[S:10][C:6]([C:4](=[O:5])[C:3]([OH:19])=[O:2])=[CH:7][N:8]=1)=[O:13])([CH3:18])([CH3:16])[CH3:17]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 86589729HCID 86589729, compound

Product 1

HCID 22349636HCID 22349636, compoundYield 82.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl(2-tert-butoxycarbonylamino-1,3-thiazole-5-yl)(oxo)acetate (1.14 g, 4 mmol) in ethanol (10 ml) was treated with sodium hydroxyde (2N, 4 ml, 8 mmol) for 3M minutes at room temperature. Ethanol was removed, the aqueous solution was acidified (pH 3). The solid was recovered, dried to give title product (900 mg, 82%).

Workup

  1. customEthanol was removed
  2. customThe solid was recovered
  3. customdried

Sources & evidence

ORD record
ord-84db59fea1e7438b8bf3b8cdca3f5b70
Source dataset
uspto-grants-2005_07
Patent number
US06919338B2

Reaction notes

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