反应详情

2-(3-Isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carbonitrile (110 mg, 0.275 mmol) was treated with hydroxylaminehydrochloride (57 mg, 0.275 mmol), K2CO3 (55.3 mg, 0.4 mmol) and heated to reflux in EtOH(10 ml) for 6 h. The solvent was removed and the residue dissolved in CH2Cl2 and washed with H2O. The solvent was removed to give 31 mg (26%) of N-hydroxy-2-(3-isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carboxamidine as a white solid.

1. temperatureheated
2. customThe solvent was removed
3. dissolutionthe residue dissolved in CH2Cl2
4. washwashed with H2O
5. customThe solvent was removed