Potassium Carbonate → HCID 22351066, compound

HRID 896490Notes

Reaction equation

HRID 896490 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:15]=[CH:14][C:9]2[NH:10][C:11](=[O:13])[S:12][C:8]=2[CH:7]=1)=[O:5].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:27][CH2:28][O:29][C:30]1[CH:45]=[CH:44][C:33]([CH:34]=[C:35]([C:40]([O:42][CH3:43])=[O:41])[C:36]([O:38][CH3:39])=[O:37])=[CH:32][CH:31]=1>CN(C=O)C>[Cl:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:15]=[CH:14][C:9]2[N:10]([CH2:27][CH2:28][O:29][C:30]3[CH:31]=[CH:32][C:33]([CH:34]=[C:35]([C:40]([O:42][CH3:43])=[O:41])[C:36]([O:38][CH3:39])=[O:37])=[CH:44][CH:45]=3)[C:11](=[O:13])[S:12][C:8]=2[CH:7]=1)=[O:5]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 10424286HCID 10424286, compoundHCID 22351129HCID 22351129, compound

Product 1

HCID 22351066HCID 22351066, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

The compound obtained in Step A is dissolved in DMF and 2 equivalents of potassium carbonate are added. After stirring for 20 minutes at 80° C., 1.2 equivalents of dimethyl 2-[4-(2-chloroethoxy)benzylidene]malonate are added and the reaction is heated for 12 hours. The reaction mixture is then hydrolysed in water and filtered, and the resulting precipitate is recrystallised from methanol to yield the title product.

Workup

  1. temperaturethe reaction is heated for 12 hours
  2. filtrationhydrolysed in water and filtered
  3. customthe resulting precipitate is recrystallised from methanol

Sources & evidence

ORD record
ord-d5c33648a6d44b45b102affad1d7a422
Source dataset
uspto-grants-2005_07
Patent number
US06919362B2

Reaction notes

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