反应详情

5-Methyl-5-phenylimidazolidine-2,4-dione potassium salt (228 mg) was suspended in tetrahydrofuran (5 mL), 1-naphthoyl chloride (188 mg) was added, and the mixture was stirred at room temperature overnight. To the reaction solution was added ethyl acetate (20 mL), and the mixture was filtered with a membrane filter (0.25 μm). After the solvent was distilled off, 364 mg of the resulting organic layer was purified by silica gel chromatography (hexane:ethyl acetate=2:1). Further recrystallization from ethyl acetate/IPE afforded 134 mg of white crystals.

1. filtrationthe mixture was filtered with a membrane
2. filtrationfilter (0.25 μm)
3. distillationAfter the solvent was distilled off
4. custom364 mg of the resulting organic layer was purified by silica gel chromatography (hexane:ethyl acetate=2:1)
5. customFurther recrystallization from ethyl acetate/IPE