反应详情

5,5-Dimethyl-2,4-oxazolidinedione potassium salt (84 mg) was suspended in tetrahydrofuran (1 mL), 1-naphthoyl chloride (95 mg) was added, and the mixture was stirred at room temperature overnight. To the reaction solution was added 4 mL of ethyl acetate, and the solution was filtered with a membrane filter (0.25 μm). The resulting organic layer was purified by silica gel chromatography (hexane:ethyl acetate=2:1), and further recrystallized from ethyl acetate/IPE to obtain 61 mg of white crystals.

1. filtrationthe solution was filtered with a membrane
2. filtrationfilter (0.25 μm)
3. customThe resulting organic layer was purified by silica gel chromatography (hexane:ethyl acetate=2:1)
4. customfurther recrystallized from ethyl acetate/IPE