Water → HCID 22350093, compound

HRID 896664Notes

Reaction equation

HRID 896664 reaction equation
[CH2:1]([SH:3])[CH3:2].[CH3:4][S:5]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12]Cl)=[CH:10][CH:9]=1)(=[O:7])=[O:6].C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[CH2:1]([S:3][CH2:12][C:11]1[CH:10]=[CH:9][C:8]([S:5]([CH3:4])(=[O:7])=[O:6])=[CH:15][CH:14]=1)[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 6343EthanethiolHCID 10796Cesium carbonateHCID 1235301-(Chloromethyl)-4-methanesulfonylbenzene

Product 1

HCID 22350093HCID 22350093, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of ethanethiol (0.3 mL, 4.9 mmol) and 4-methanesulfonylbenzyl chloride (1 g, 4,9 mmol) in DMF (10 mL) at 21° C. was added cesium carbonate (0.8 g, 2.5 mmol). After 18 h, the reaction mixture was poured into water and then filtered off to provide the 1-ethylsulfanylmethyl-4-methanesulfonyl-benzene compound as a white solid.

Workup

  1. filtrationfiltered off

Sources & evidence

ORD record
ord-c814f3c3e21247f085a1cc6bff83a5d6
Source dataset
uspto-grants-2005_07
Patent number
US06919353B2

Reaction notes

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