反应详情

A mixture of Boc-Aze-OH (5 g, 25 mmol) and HOSu (2.88 g, 25 mmol) in 25 ml of THF was cooled on an ice bath EDC (4.3 ml, 25 mmol) was added and the solution was stirred overnight. It was evaporated, dissolved in ethyl acetate, washed with KHSO4 (aq, 0.3 M), Na2CO3 (aq, 10%), dried (MgSO4) and evaporated. Crystallization from ethyl acetate:petroleum ether afforded 3.78 g (51%) of sub-title compound.

1. additionwas added
2. customIt was evaporated
3. dissolutiondissolved in ethyl acetate
4. washwashed with KHSO4 (aq, 0.3 M), Na2CO3 (aq, 10%)
5. dry with materialdried (MgSO4)
6. customevaporated
7. customCrystallization from ethyl acetate