Thiophenol → HCID 22320547, compound

HRID 897194Notes

Reaction equation

HRID 897194 reaction equation
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[CH2:10]([C:14]1[N:15]([CH2:28][CH2:29][CH2:30]Cl)[C:16]2[C:25]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[N:19]=[C:18]([NH2:26])[C:17]=2[N:27]=1)[CH2:11][CH2:12][CH3:13]>CN(C)C=O>[CH2:10]([C:14]1[N:15]([CH2:28][CH2:29][CH2:30][S:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:16]2[C:25]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[N:19]=[C:18]([NH2:26])[C:17]=2[N:27]=1)[CH2:11][CH2:12][CH3:13]

Participants

5

Reactant 3

HCID 7969ThiophenolHCID 24758Sodium hydrideHCID 22320517HCID 22320517, compound

Product 1

HCID 22320547HCID 22320547, compoundYield 68.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A round bottom flask was charged with a magnetic stir bar, benzenethiol (0.68 g, 6.21 mmol), sodium hydride (0.25 g, 60% dispersion, 6.21 mmol), and anhydrous dimethyl formamide (28 mL) under a nitrogen atmosphere. After the reaction mixture had stirred at ambient temperature for 30 minutes, 2-butyl-1-(3-chloropropyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.64 g, 5.18 mmol) was added and the resulting cloudy solution was was completely consumed. The hot solution was poured into rapidly stirred water (200 mL). The resulting mixture was extracted with chloroform (2×). The combined organic layers were washed with saturated aqueous sodium bicarbonate and brine, dried over anhydrous sodium sulfate, filtered and then concentrated under reduced pressure to afford a light yellow oil. The material was purified by chromatography over silica gel (95/5 dichloromethane/methanol) to provide 2-butyl-1-[3-(phenylthio)propyl]-1H-imidazo[4,5-c]quinolin-4-amine (1.38 g, 3.53 mmol) as a white solid.

Workup

  1. additionA round bottom flask was charged with a magnetic stir bar
  2. customthe resulting cloudy solution was was completely consumed
  3. additionThe hot solution was poured into rapidly stirred water (200 mL)
  4. extractionThe resulting mixture was extracted with chloroform (2×)
  5. washThe combined organic layers were washed with saturated aqueous sodium bicarbonate and brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customto afford a light yellow oil
  10. customThe material was purified by chromatography over silica gel (95/5 dichloromethane/methanol)

Sources & evidence

ORD record
ord-5508ef21e85a4eef90c8884451e295a8
Source dataset
uspto-grants-2005_07
Patent number
US06921826B2

Reaction notes

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