Water → HCID 22346353, compound

HRID 897353Notes

Reaction equation

HRID 897353 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([S:7](Cl)(=[O:9])=[O:8])[N:4]=[CH:3]1.[CH3:11][NH2:12].O>C(Cl)Cl.C1COCC1>[CH3:11][NH:12][S:7]([C:5]1[N:4]=[CH:3][N:2]([CH3:1])[CH:6]=1)(=[O:9])=[O:8]

Participants

6

Reactant 3

HCID 962WaterHCID 6329MethylamineHCID 27368871-methyl-1H-imidazole-4-sulfonyl chloride

Product 1

HCID 22346353HCID 22346353, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (1-methyl-1H-imidazol-4-yl)sulfonyl chloride (3.14 g, 17.4 mmol) in methylene chloride was added a solution of methylamine (26 mL of a 2M solution in THF, 52 mmol). The resulting mixture was stirred at room temperature for 16 hr. Water (25 mL) was added and the mixture was extracted with methylene chloride (2×100 mL). The combined organic extracts were washed with water (10 mL) and dried (MgSO4). The solvent was evaporated in vacuo to afford the title compound.

Workup

  1. extractionthe mixture was extracted with methylene chloride (2×100 mL)
  2. washThe combined organic extracts were washed with water (10 mL)
  3. dry with materialdried (MgSO4)
  4. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-057b38fb534c42b084b1296362c8d845
Source dataset
uspto-grants-2005_07
Patent number
US06921759B2

Reaction notes

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