反应详情

To a solution of (1-methyl-1H-imidazol-4-yl)sulfonyl chloride (3.14 g, 17.4 mmol) in methylene chloride was added a solution of methylamine (26 mL of a 2M solution in THF, 52 mmol). The resulting mixture was stirred at room temperature for 16 hr. Water (25 mL) was added and the mixture was extracted with methylene chloride (2×100 mL). The combined organic extracts were washed with water (10 mL) and dried (MgSO4). The solvent was evaporated in vacuo to afford the title compound.

1. extractionthe mixture was extracted with methylene chloride (2×100 mL)
2. washThe combined organic extracts were washed with water (10 mL)
3. dry with materialdried (MgSO4)
4. customThe solvent was evaporated in vacuo