Ethyl Acetoacetate → Ethyl 3-hydroxypentanoate

HRID 898504Notes

Reaction equation

[C:1]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])[CH2:2][CH3:3].C(OCC)(=O)CC(C)=O>>[OH:4][CH:1]([CH2:2][CH3:3])[CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 78656Ethyl 3-oxovalerate

Product 1

HCID 316884Ethyl 3-hydroxypentanoateYield 50%

Procedure

Ethyl 3-hydroxyvalerate was prepared following the procedure as described in step 1) of Preparation Example 2, except for that ethyl propionylacetate was used to replace for ethyl acetoacetate. Yield 50%.

Workup

customof Preparation Example 2

Sources & evidence

ORD record: ord-0858150be08f46adb9c69611360987a0
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07351778B2

Reaction notes

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