Ethyl Acetoacetate → Ethyl 3-hydroxyhexanoate

HRID 898505Notes

Reaction equation

[C:1]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:5])[CH2:2][CH2:3][CH3:4].C(OCC)(=O)CC(C)=O>>[OH:5][CH:1]([CH2:2][CH2:3][CH3:4])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 238498Ethyl 3-oxohexanoate

Product 1

HCID 61293Ethyl 3-hydroxyhexanoateYield 48%

Procedure

Ethyl 3-hydroxycaproate was prepared following the procedure as described in step 1) of Preparation Example 2, except for that ethyl butyrylacetate was used to replace for ethyl acetoacetate. Yield 48%.

Workup

customof Preparation Example 2

Sources & evidence

ORD record: ord-c037db2a595140a98eb3440a2b2b627e
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07351778B2

Reaction notes

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