反应详情

温度

100 °C

14.5 mL (83.242 mmol) Hünig base was added to a solution of 7.800 g (37.222 mmol) 4-bromo-2-chlorophenol and 4.70 mL (41.537 mmol) ethyl bromoacetate in 100 mL DMF and the mixture was stirred for 4 h at 100° C. The reaction mixture was combined with water and exhaustively extracted with EtOAc. The combined org. phases were washed with saturated aqueous sodium bicarbonate, water and saturated aqueous NaCl, dried over sodium sulphate and evaporated down i. vac. The crude product was used in the next reaction step without any further purification.

1. extractionexhaustively extracted with EtOAc
2. washphases were washed with saturated aqueous sodium bicarbonate, water and saturated aqueous NaCl
3. dry with materialdried over sodium sulphate
4. customevaporated down i
5. customThe crude product was used in the next reaction step without any further purification