反应详情

A solution of 3.66 mL (41.56 mmol) 1,2-dibromoethane in 5 mL DMF was slowly added at RT to a suspension of 1.580 g (4.156 mmol) N-(3-chloro-4-hydroxy-phenyl)-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide and 2.880 g (8.310 mmol) potassium carbonate in 20 mL DMF and the mixture was stirred for 2.5 h. The reaction mixture was evaporated down i. vac. and diluted with EtOAc . The org. phase was washed with water and saturated aqueous NaCl, dried over magnesium sulphate and evaporated down i. vac. Column chromatography (silica gel, petroleum ether→dichloromethane) yielded the product.

1. customThe reaction mixture was evaporated down i
2. additionand diluted with EtOAc
3. washphase was washed with water and saturated aqueous NaCl
4. dry with materialdried over magnesium sulphate
5. customevaporated down i
6. customColumn chromatography (silica gel, petroleum ether→dichloromethane) yielded the product