Potassium Carbonate → HCID 68875187, compound

HRID 898565Notes

Reaction equation

HRID 898565 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[OH:12].Br[CH:14]([CH3:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:5]=[CH:4][C:3]=1[O:12][CH:14]([CH3:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionateHCID 27366032-Chloro-4-(trifluoromethyl)phenol

Product 1

HCID 68875187HCID 68875187, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

10.00 g (50.87 mmol) of 2-chloro-4-trifluoromethyl-phenol, 7.11 mL (55.00 mmol) of ethyl 2-bromopropionate and 7.60 g (55 mmol) of potassium carbonate in 100 mL DMF was stirred for 16 hours at 50° C. and then filtered. The filtrate was evaporated down i. vac., combined with water and exhaustively extracted with EtOAc. The combined org. extracts were washed with 10% aqueous sodium carbonate solution and water, dried over sodium sulphate and evaporated down i. vac.

Workup

  1. filtrationfiltered
  2. customThe filtrate was evaporated down i
  3. extractionexhaustively extracted with EtOAc
  4. washextracts were washed with 10% aqueous sodium carbonate solution and water
  5. dry with materialdried over sodium sulphate
  6. customevaporated down i

Sources & evidence

ORD record
ord-55260ef02cf7483895fd81aa623e6b72
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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