反应详情

A solution of 0.290 g (0.603 mmol) (E)-N-[4-(3-bromo-propyl)-3-chloro-phenyl]-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide (Z45d) in 2 mL diethylamine was heated to 100° C. in a sealed reaction vessel in the microwave for 5 min. The reaction mixture was diluted with EtOAc, the org. phase was washed with water, dried over sodium sulphate and evaporated down i. vac. The residue was triturated with ether, the precipitate was filtered off, washed with ether and dried in a HV.

1. washphase was washed with water
2. dry with materialdried over sodium sulphate
3. customevaporated down i
4. customThe residue was triturated with ether
5. filtrationthe precipitate was filtered off
6. washwashed with ether
7. customdried in a HV