反应详情

温度

61.5 °C

1360 g of 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione (VI) are suspended in 10.2 l of ethanol at 22° C., and 1103 g of methylamine solution (40% strength in water) are added. The reaction mixture is then heated to 60 to 63° C., and the resulting solution is stirred at this temperature for 2 hours. After cooling to 55 to 60° C., a total of 2348 g of hydrochloric acid solution (20% strength in water) is added until the pH is 2.7, after which the product starts to crystallize. After cooling to 20° C., the precipitated reaction product is filtered off with suction, washed with methanol and then dried.

1. temperatureAfter cooling to 55 to 60° C.
2. customto crystallize
3. temperatureAfter cooling to 20° C.
4. customthe precipitated reaction product
5. filtrationis filtered off with suction
6. washwashed with methanol
7. customdried