HCID 69215509, compound → HCID 69215235, compound

HRID 898666Notes

Reaction equation

HRID 898666 reaction equation
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11]CC2C=CC=CC=2)=[C:7]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[C:6]=1[F:24])(=[O:3])[CH3:2]>[Pd].C(OCC)(=O)C>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[C:6]=1[F:24])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 69215509HCID 69215509, compound2×

Product 1

HCID 69215235HCID 69215235, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Following General Procedure G and using acetoxymethyl-4-benzyloxy-2-fluoro-phenyl acetate (Compound 20, 0.75 g, 2.26 mmol), ethyl acetate (15 mL) and 10% palladium on carbon (0.08 g), the title compound was obtained as an oil (0.48 g, 88%). 1H-NMR (300 MHz, CDCl3): δ2.09 (s, 3H), 3.62 (s, 2H), 5.75 (s, 2H), 6.48-6.54 (m, 2H), 7.02 (d, J=8.4 Hz, 1H).

Sources & evidence

ORD record
ord-6c05b8806f494ffd8869646ea05219dd
Source dataset
uspto-grants-2008_04
Patent number
US07351737B2

Reaction notes

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