Hydrazine hydrate (1:1) → (6-Methyl-5-propyl-pyrimidin-4-yl)-hydrazine

HRID 898706Notes

Reaction equation

HRID 898706 reaction equation
[CH2:1]([C:4]1[C:5](Cl)=[N:6][CH:7]=[N:8][C:9]=1[CH3:10])[CH2:2][CH3:3].O.[NH2:13][NH2:14]>C(O)C>[CH3:10][C:9]1[N:8]=[CH:7][N:6]=[C:5]([NH:13][NH2:14])[C:4]=1[CH2:1][CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 223131564-Chloro-6-methyl-5-propylpyrimidine

Product 1

HCID 55281290(6-Methyl-5-propyl-pyrimidin-4-yl)-hydrazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 5-propyl-4-chloro-6-methyl-pyrimidine (10 mmol) and hydrazine monohydrate (30 mmol) in ethanol (20 mL) is heated at 80° C. overnight. Solvent is removed in vacuo and the residue solid is in the next step without further purification.

Workup

  1. customSolvent is removed in vacuo
  2. customthe residue solid is in the next step without further purification

Sources & evidence

ORD record
ord-3775f99fbe434de3b2e2bdabf0ff50f2
Source dataset
uspto-grants-2008_04
Patent number
US07351826B2

Reaction notes

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