Hydrochloric Acid → [Allyl-(5,6-dichloro-pyridin-3-yl)-amino]-acetaldehyde

HRID 898738Notes

Reaction equation

HRID 898738 reaction equation
[CH2:1]([N:4]([C:11]1[CH:12]=[N:13][C:14]([Cl:18])=[C:15]([Cl:17])[CH:16]=1)[CH2:5][CH:6](OC)[O:7]C)[CH:2]=[CH2:3].Cl.ClCCl>O1CCCC1.O>[CH2:1]([N:4]([CH2:5][CH:6]=[O:7])[C:11]1[CH:12]=[N:13][C:14]([Cl:18])=[C:15]([Cl:17])[CH:16]=1)[CH:2]=[CH2:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 57448418Allyl-(5,6-dichloro-pyridin-3-yl)-(2,2-dimethoxy-ethyl)amine

Product 1

HCID 57448419[Allyl-(5,6-dichloro-pyridin-3-yl)-amino]-acetaldehyde

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
15 °C

Procedure

A solution of allyl-(5,6-dichloro-pyridin-3-yl)-(2,2-dimethoxy-ethyl)-amine (57.2 g) in tetrahydrofuran (443 g) was cooled to 10° C. A solution of concentrated hydrochloric acid (136 g) in water (114 g) was slowly added, maintaining the temperature below 20° C. The reaction was then stirred at 15° C. for about 4 hours. Then dichloromethane (570 g) and water (430 g) were added and the layers separated. The organic layer was washed with 5% aqueous sodium bicarbonate (453 g), and then washed twice with water (430 g). The organic layer was concentrated and the residue dissolved in dichloromethane (580 g).

Workup

  1. temperaturemaintaining the temperature below 20° C
  2. customthe layers separated
  3. washThe organic layer was washed with 5% aqueous sodium bicarbonate (453 g)
  4. washwashed twice with water (430 g)
  5. concentrationThe organic layer was concentrated
  6. dissolutionthe residue dissolved in dichloromethane (580 g)

Sources & evidence

ORD record
ord-a9ed1b4d10ec401c81c965c23b6b8bf1
Source dataset
uspto-grants-2008_04
Patent number
US07351833B2

Reaction notes

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