Hydrochloric Acid → 1-[2-(4-Pyridinyl)ethyl]piperazine hydrochloride

HRID 898806Notes

Reaction equation

HRID 898806 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.C(OCC)(=O)C.[ClH:28]>C(OCC)C>[ClH:28].[N:19]1[CH:20]=[CH:21][C:16]([CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 223216311-Boc-4-[2-(4-pyridinyl)ethyl]piperazine

Product 1

HCID 223217641-[2-(4-Pyridinyl)ethyl]piperazine hydrochlorideYield 87%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Alternatively, 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine (1.0 g, 3.43 mmol) was dissolved in ethyl ether. Ethyl acetate (15 mL) saturated with HCl was added, and the mixture stirred for 30 min at room temperature. The mixture was concentrated under vacuum and provided 1-[2-(4-pyridinyl)-ethyl]piperazine hydrochloride (900 mg, 87%) as a tan solid.

Workup

  1. concentrationThe mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-d47d6797a275408f8d4964aa94422349
Source dataset
uspto-grants-2008_04
Patent number
US07351822B2

Reaction notes

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