Hydrochloric Acid → HCID 86607501, compound

HRID 898853Notes

Reaction equation

HRID 898853 reaction equation
C(OC(=O)[NH:7][C@:8]1([C:20](=[O:25])[N:21]([O:23][CH3:24])[CH3:22])[C@@H:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C@H:9]1[CH2:17][O:18][CH3:19])(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[CH3:24][O:23][N:21]([CH3:22])[C:20]([C@@:8]1([NH2:7])[C@@H:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C@H:9]1[CH2:17][O:18][CH3:19])=[O:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86623929HCID 86623929, compound

Product 1

HCID 86607501HCID 86607501, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

[(1R*,2R*,3R*)-2-methoxymethyl-1-(methoxy-methyl-carbamoyl)-3-phenyl-cyclopropyl]-carbamic acid t-butyl ester (25 mg, 0.69 mmol) was dissolved in 4 mL of HCl in dioxane (4M). After stirring at room temperature for 1 hour, the solution was concentrated and dried under high vacuum to afford 100% of an HCl salt product.

Workup

  1. concentrationthe solution was concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-c38b12e34a4b4203988932b54dcced04
Source dataset
uspto-grants-2008_04
Patent number
US07351825B2

Reaction notes

Loading…