Hydrochloric Acid → 2-(5-Fluoro-2-methoxy-phenyl)-1-morpholin-2-yl-1-phenyl-ethanol hydrochloride

HRID 899091Notes

Reaction equation

HRID 899091 reaction equation
CO.C([N:10]1[CH2:15][CH2:14][O:13][CH:12]([C:16]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([OH:27])[CH2:17][C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[O:25][CH3:26])[CH2:11]1)C1C=CC=CC=1.[ClH:34].C(O)C>[Pd].C(O)(C)C>[ClH:34].[F:24][C:22]1[CH:21]=[CH:20][C:19]([O:25][CH3:26])=[C:18]([CH2:17][C:16]([CH:12]2[O:13][CH2:14][CH2:15][NH:10][CH2:11]2)([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[OH:27])[CH:23]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 887MethanolHCID 692913681-(4-Benzyl-morpholin-2-yl)-2-(5-fluoro-2-methoxy-phenyl)-1-phenyl-ethanol

Product 1

HCID 692929272-(5-Fluoro-2-methoxy-phenyl)-1-morpholin-2-yl-1-phenyl-ethanol hydrochlorideYield 88.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 3776IsopropanolSolvent

Procedure

Alternatively, the following method may be used. A glass hydrogenation flask was loaded with methanol (1.55 L), Pd/C (10%, 31 g, 20% loading), 1-(4-benzyl-morpholin-2-yl)-2-(5-fluoro-2-methoxy-phenyl)-1-phenyl-ethanol (155 g, 0.368 mole) and a solution of HCl in ethanol (2.5N, 233 ml, 0.582 mole, 1.6 eq.). The reactor was mounted on a Parr instrument and pressurized with H2 (49 Psi). The reaction mixture was shaken overnight between 20° C. and 15° C. The catalyst was filtered off and washed with methanol (0.5 L). The filtrates were concentrated under vacuum. The yield of crude title compound was 109.5 g (81%). The catalyst was washed again with methanol (2×500 ml). The filtrates were combined and concentrated under vacuum. The yield of the second crop of crude title compound was 21.7 g (16%). A reactor was loaded with crude title compound (131 g, 0.356 mole) and isopropanol (1.3 L) under N2. The suspension was heated under reflux for 4 hours. The mixture was cooled to 20° C. and the solid was filtered, washed with isopropanol (130 ml), and dried at 50° C. under vacuum. The yield of pure title compound was 115.9 g (88.5% yield).

Workup

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol (0.5 L)
  3. concentrationThe filtrates were concentrated under vacuum
  4. washThe catalyst was washed again with methanol (2×500 ml)
  5. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-a87047f5984c4a88819fff87c008e4e0
Source dataset
uspto-grants-2008_04
Patent number
US07354920B2

Reaction notes

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