Hydrochloric Acid → Hydrochloric Acid

HRID 899160Notes

Reaction equation

HRID 899160 reaction equation
[ClH:1].C(OC(=O)[N:8]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:9][CH2:10][N:11]1[CH2:18][CH:17]2[O:19][CH:13]([CH2:14][N:15]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][CH:22]=3)[CH2:16]2)[CH2:12]1)(C)(C)C>O1CCOCC1.C(OCC)C>[ClH:1].[CH2:29]([NH:8][CH2:9][CH2:10][N:11]1[CH2:12][CH:13]2[O:19][CH:17]([CH2:16][N:15]([CH2:20][C:21]3[CH:22]=[CH:23][C:24]([C:27]#[N:28])=[CH:25][CH:26]=3)[CH2:14]2)[CH2:18]1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 69067859HCID 69067859, compound

Product 2

HCID 313Hydrochloric AcidHCID 69071248HCID 69071248, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent2×

Procedure

Dioxane saturated with HCl gas (10 ml) was added to a solution of benzyl-{2-[7-(4-cyano-benzyl)-9-oxa-3,7-diaza-bicyclo[3.3.1 ]non-3-yl]-ethyl}-carbamic acid tert-butyl ester (0.65 g, from step (ii) above in 5 ml of dioxane and stirred for 1 h at RT under nitrogen atmosphere. The reaction mixture was diluted with dry diethylether, and the solvent was decanted. Precipitated solid was washed with dry diethylether (4 times) and dried under vacuum to give HCl salt of the sub-title compound (0.5 g) as a powder.

Workup

  1. customthe solvent was decanted
  2. customPrecipitated solid
  3. washwas washed with dry diethylether (4 times)
  4. customdried under vacuum

Sources & evidence

ORD record
ord-72e07a790e2a4764aeef148f30f0d8e7
Source dataset
uspto-grants-2008_04
Patent number
US07354917B2

Reaction notes

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