HCID 69216306, compound → HCID 69214221, compound

HRID 899283Notes

Reaction equation

HRID 899283 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-])=O)[CH:12]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2].[H][H]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:20])[CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([NH2:17])[CH:12]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2]

Participants

5

Reactant 2

HCID 69216306HCID 69216306, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69214221HCID 69214221, compoundYield 97.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-(3-nitro-phenyl)-heptanoic acid ethyl ester (4.451 g, 15.9 mmole) in 150 mL of ethyl acetate containing 1.69 g of 10% palladium on carbon was subjected to atmospheric pressure of hydrogen for 15 hours. The mixture was filtered through a Celite/SiO2 pad and the volatiles were removed in vacuo to yield 3.866 g of 2-(3-amino-phenyl)-heptanoic acid ethyl ester as a pale yellow oil.

Workup

  1. filtrationThe mixture was filtered through a Celite/SiO2 pad
  2. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-028349c1834441509f651ccd7659d161
Source dataset
uspto-grants-2008_04
Patent number
US07354931B2

Reaction notes

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