Hydrazine hydrate (1:1) → HCID 59104129, compound

HRID 899381Notes

Reaction equation

HRID 899381 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[CH:12]([N:14]1C(=O)C2C(=CC=CC=2)C1=O)[CH3:13].O.NN>CO>[NH2:14][CH:12]([C:3]1[CH:4]=[CH:5][C:6]([C:8]([OH:11])([CH3:9])[CH3:10])=[CH:7][C:2]=1[F:1])[CH3:13]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59104146HCID 59104146, compound

Product 1

HCID 59104129HCID 59104129, compoundYield 116.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 158 mg (0.48 mmol) (±)-2-[1-[2-fluoro-4-[1-hydroxy-1-methyl-ethyl]-phenyl]-ethyl]-isoindole-1,3-dione and 0.08 ml (2.4 mmol) hydrazine hydrate in 10 ml methanol was stirred at room temperature overnight. The resulting precipitate was filtered and the filtrate concentrated to give a solid. The solid was triturated with chloroform, filtered and the filtrate was then concentrated to give 110 mg (100%) oil.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. concentrationthe filtrate concentrated
  3. customto give a solid
  4. customThe solid was triturated with chloroform
  5. filtrationfiltered
  6. concentrationthe filtrate was then concentrated

Sources & evidence

ORD record
ord-8bc4bc9984ff417297315bdbc5321bd4
Source dataset
uspto-grants-2008_04
Patent number
US07354941B2

Reaction notes

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