反应详情

温度

-20 °C

To a solution of (R)-(5,6,7,8-tetrahydro-quinolin-8-yl)amine (70.0 g, 0.47 mol) and 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyraldehyde (102.59 g, 0.47 mol) in tetrahydrofuran (160 mL) at room temperature was added potassium carbonate (65.28 g, 0.47 mol) and the mixture stirred for 1 hour. The suspension was then filtered and chilled to −20° C. The cold filtrate was slowly added to Solution A via canula over 35 minutes. The resulting mixture was stirred at −20° C. for 1 hour, until reaction was complete by NMR aliquot. The reaction was then neutralized by the careful addition of 6N HCl until pH=2-3, keeping the temperature below −7° C. The solution was then warmed to 22° C. and basified with 13 w/v % Na2CO3(aq) until pH=4. The tetrahydrofuran was removed under reduced pressure and the concentrate diluted with water (700 mL) and CH2Cl2 (530 mL). The phases were separated and the organic phase washed with concentrated ammonium hydroxide (1×230 mL) and water (1×315 mL). The organic phase was then concentrated to 200-250 mL and filtered through a conditioned silica gel pad (14 g). The silica gel was rinsed with CH2Cl2 (2×20 mL). The combined filtrate was concentrated to 100-150 mL and diluted with diisopropyl ether (1000 mL). The solution was concentrated to 300-350 mL and chilled to −10° C., at which temperature the product began to precipitate. Mechanical stirring was continued for 45 minutes at −10° C., after which time the product was collected by filtration. The product was washed with diisopropyl ether (100 mL) and dried under reduced pressure to give pure 2-{4-[(R)-(5,6,7,8-tetrahydro-quinolin-8-yl)amino]-butyl}-isoindole-1,3-dione (135.3 g, 82%). 1H NMR (300 MHz, CDCl3, δ ppm) 1.55-1.85 (m, 6H), 1.95-2.05 (m, 1H), 2.05-2.20 (m, 1H), 2.50 (b, 1H), 2.65-2.85 (m, 4H), 3.65-3.80 (m, 3H), 7.04 (dd, 1H, J=4.5 & 7.5 Hz), 7.35 (d, 1H, J=7.5 Hz), 7.65-7.75 (m, 2H), 7.75-7.85 (m, 2H), 8.36 (d, 1H, J=4.5 Hz).

1. filtrationThe suspension was then filtered
2. additionThe cold filtrate was slowly added to Solution A via canula over 35 minutes
3. stirringThe resulting mixture was stirred at −20° C. for 1 hour, until reaction
4. additionThe reaction was then neutralized by the careful addition of 6N HCl until pH=2-3
5. customthe temperature below −7° C
6. temperatureThe solution was then warmed to 22° C. and basified with 13 w/v % Na2CO3(aq) until pH=4
7. customThe tetrahydrofuran was removed under reduced pressure
8. additionthe concentrate diluted with water (700 mL) and CH2Cl2 (530 mL)
9. customThe phases were separated
10. washthe organic phase washed with concentrated ammonium hydroxide (1×230 mL) and water (1×315 mL)
11. concentrationThe organic phase was then concentrated to 200-250 mL
12. filtrationfiltered through a conditioned silica gel pad (14 g)
13. washThe silica gel was rinsed with CH2Cl2 (2×20 mL)
14. concentrationThe combined filtrate was concentrated to 100-150 mL
15. additiondiluted with diisopropyl ether (1000 mL)
16. concentrationThe solution was concentrated to 300-350 mL
17. temperaturechilled to −10° C., at which temperature the product
18. customto precipitate
19. stirringMechanical stirring
20. waitwas continued for 45 minutes at −10° C.
21. filtrationafter which time the product was collected by filtration
22. washThe product was washed with diisopropyl ether (100 mL)
23. customdried under reduced pressure