反应详情

Methyl 2-[(4-{3-[(3-ethoxypropyl)(4-isopropylbenzyl)amino]-3-oxopropyl}phenoxy)methyl]benzoate (0.16 g, 0.30 mmol) was dissolved in THF/water (2/1, 2 ml) and LiOH (14.4 mg, 0.60 mmol) was added. The reaction was performed in a single node microwave oven (150° C., 7 min). Workup was done by adding EtOAc (10 ml) and washing the organic phase with two portions of HCl (2×5 ml, 1 M). The organic phase was dried (MgSO4) and the solvent was removed by evaporation to give 0.108 gram of 2-[(4-{3-[(3-ethoxypropyl)(4-isopropylbenzyl)amino]-3-oxopropyl}phenoxy)methyl]benzoic acid (yield 69.3%).

1. customThe reaction was performed in a single node microwave oven
2. custom(150° C., 7 min)
3. washwashing the organic phase with two portions of HCl (2×5 ml, 1 M)
4. dry with materialThe organic phase was dried (MgSO4)
5. customthe solvent was removed by evaporation