HCID 69217957, compound → HCID 11682750, compound

HRID 900162Notes

Reaction equation

HRID 900162 reaction equation
COC1C=C(OC)C=CC=1C[N:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14]([NH:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[C:9]=2[C:8]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[C:7]1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>FC(F)(F)C(O)=O>[C:24]1([C:8]2[C:9]3[C:14]([NH:15][CH2:16][CH2:17][N:18]4[CH2:19][CH2:20][O:21][CH2:22][CH2:23]4)=[N:13][CH:12]=[N:11][C:10]=3[NH:6][C:7]=2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 1

HCID 69217957HCID 69217957, compound

Product 1

HCID 11682750HCID 11682750, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of [7-(2,4-Dimethoxybenzyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-(2-morpholin-4-ylethyl)-amine (54 mg, 0.1 mmol) in 2 mL of trifluoroacetic acid was heated to reflux. After 18 hours, the solution was concentrated to dryness and purified by preparative HPLC (C8 column, water, acetonitrile, 0.1% TFA) to give the title compound. Mass Spectrum (ESI) m/e=400 (M+1).

Workup

  1. concentrationthe solution was concentrated to dryness
  2. custompurified by preparative HPLC (C8 column, water, acetonitrile, 0.1% TFA)

Sources & evidence

ORD record
ord-fab9b2ed780b475dbbd614f1a12d68cf
Source dataset
uspto-grants-2008_04
Patent number
US07358250B2

Reaction notes

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