Sulpiride → HCID 11451902, compound

HRID 900175Notes

Reaction equation

HRID 900175 reaction equation
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH:9][C:10](=[O:23])[C:11]1[CH:16]=[C:15]([S:17](=[O:20])(=[O:19])[NH2:18])[CH:14]=[CH:13][C:12]=1[O:21][CH3:22])[CH3:2].[C:24](OC(=O)C)(=[O:26])[CH3:25].C(N(CC)CC)C>O>[C:24]([NH:18][S:17]([C:15]1[CH:14]=[CH:13][C:12]([O:21][CH3:22])=[C:11]([CH:16]=1)[C:10]([NH:9][CH2:8][CH:4]1[CH2:5][CH2:6][CH2:7][N:3]1[CH2:1][CH3:2])=[O:23])(=[O:19])=[O:20])(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 5355SulpirideHCID 7918Acetic AnhydrideHCID 8471Triethylamine

Product 1

HCID 11451902HCID 11451902, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide, acetic anhydride and triethylamine are reacted at room temperature, diluted with water and extracted with ethyl acetate. The ethyl acetate layer is dried, filtered and concentrated under vacuum, and the residue recrystallized from ethyl acetate.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate layer is dried
  3. filtrationfiltered
  4. concentrationconcentrated under vacuum
  5. customthe residue recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-67e3a46fbe574971a68f827107853483
Source dataset
uspto-grants-2008_04
Patent number
US07358271B2

Reaction notes

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