Dichloromethane → 3-(Carbamoylamino)-5-Phenylthiophene-2-Carboxamide

HRID 900414Notes

Reaction equation

HRID 900414 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[S:4][C:3]=1[C:13]([NH2:15])=[O:14].C[Si]([N:20]=[C:21]=[O:22])(C)C.ClCCl>CN(C)C=O>[NH2:20][C:21]([NH:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[S:4][C:3]=1[C:13]([NH2:15])=[O:14])=[O:22]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 70696Trimethylsilyl isocyanateHCID 27565343-Amino-5-phenylthiophene-2-carboxamide

Product 1

HCID 102208513-(Carbamoylamino)-5-Phenylthiophene-2-Carboxamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-Amino-5-phenyl-2-thiophenecarboxamide (0.5 g), trimethylsilylisocyanate (3 mL), dichloromethane (15 mL) and dimethylformamide (3 mL) were heated at reflux for 3 days.

Workup

  1. temperatureat reflux for 3 days

Sources & evidence

ORD record
ord-8901e10bc1ad4465acd6210ec4f1a2eb
Source dataset
uspto-grants-2008_04
Patent number
US07358376B2

Reaction notes

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