Acetic Acid → HCID 68906819, compound

HRID 900442Notes

Reaction equation

HRID 900442 reaction equation
[C:1]1([CH2:7][C:8](=O)[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:11]([CH2:13][C:14]([NH2:16])=[O:15])#[N:12].C([O-])(=O)C.[NH4+].C(O)(=O)C>C1(C)C=CC=CC=1>[C:11]([C:13](=[C:8]([CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:9])[C:14]([NH2:16])=[O:15])#[N:12]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 7678PhenylacetoneHCID 7898CyanoacetamideHCID 517165Ammonium Acetate

Product 1

HCID 68906819HCID 68906819, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of (phenyl)acetone (5 g), cyanoacetamide (3.15 g), ammonium acetate (0.29 g) and acetic acid (0.45 mL) was refluxed in toluene (50 mL) using a Dean and Stark head to remove water for 6 h. The mixture was cooled and the crystalline product was filtered off (3 g) and used without further purification.

Workup

  1. customto remove water for 6 h
  2. temperatureThe mixture was cooled
  3. filtrationthe crystalline product was filtered off (3 g)
  4. customused without further purification

Sources & evidence

ORD record
ord-e1938a78cb7446f49e3c3551a187e894
Source dataset
uspto-grants-2008_04
Patent number
US07358376B2

Reaction notes

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