Methyl iodide → HCID 22226537, compound

HRID 900721Notes

Reaction equation

HRID 900721 reaction equation
[C:1](=O)([O-])[O-].[K+].[K+].IC.[CH3:9][O:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][C:20]=1[O:21][CH3:22])[CH:17]=[N:16][CH:15]=[C:14]2[CH2:23][C:24]1[NH:32][C:31]2[C:30](=[O:33])[N:29]([CH3:34])[C:28](=[O:35])[N:27]([CH2:36][CH:37]([CH3:39])[CH3:38])[C:26]=2[N:25]=1>CN(C=O)C>[CH3:9][O:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][C:20]=1[O:21][CH3:22])[CH:17]=[N:16][CH:15]=[C:14]2[CH2:23][C:24]1[N:32]([CH3:1])[C:31]2[C:30](=[O:33])[N:29]([CH3:34])[C:28](=[O:35])[N:27]([CH2:36][CH:37]([CH3:39])[CH3:38])[C:26]=2[N:25]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 10113055HCID 10113055, compound

Product 1

HCID 22226537HCID 22226537, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Potassium carbonate (48 mg, 0.35 mmol) and iodomethane (0.018 ml,0.295 mmol) are added to a solution of the product of Example 10, 8-(6,7-dimethoxy-isoquinolin-4-ylmethyl)-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione (0.100 g, 0.24 mmol) in DMF (2 ml). The reaction is stirred overnight and purified by preparative HPLC to afford 8-(6,7-dimethoxy-isoquinolin-4-ylmethyl)-3-isobutyl-1,7-dimethyl-3,7-dihydro-purine-2,6-dione, [MH]+ 438.

Workup

  1. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-13024a6b740043a79936e047f07ac077
Source dataset
uspto-grants-2008_04
Patent number
US07361661B2

Reaction notes

Loading…