Methyl iodide → HCID 178503395, compound

HRID 900729Notes

Reaction equation

HRID 900729 reaction equation
ClCCl.N1C=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[C:12]([SH:15])[NH:13][N:14]=2)[CH:5]=1.I[CH3:17].[CH2:18]([N:20](CC)CC)C>>[CH3:17][S:15][C:12]1[NH:13][N:14]=[C:10]([C:6]2[CH:5]=[CH:18][N:20]=[CH:8][CH:7]=2)[N:11]=1

Participants

5

Reactant 4

HCID 6328Methyl iodideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 178527843HCID 178527843, compound

Product 1

HCID 178503395HCID 178503395, compound

Procedure

To a dichloromethane solution of 5-pyridin-3-yl-2H-[1,2,4]triazole-3-thiol (Step B, Example 1) triethylamine was added followed by iodomethane. This solution was stirred at room temperature for 2 h, during which period the reaction was complete by RP-HPLC. The solvent was evaporated and the residue was purified by RP-HPLC affording the desired intermediate.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by RP-HPLC

Sources & evidence

ORD record
ord-4384b5969b6a42de81f324561fde1ab6
Source dataset
uspto-grants-2008_04
Patent number
US07361669B2

Reaction notes

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