Sodium Sulfite → HCID 23086897, compound

HRID 900838Notes

Reaction equation

HRID 900838 reaction equation
CS[C:3]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[CH:9]=2)[S:5][N:4]=1.Cl[C:16]1C=C(C=CC=1)C(OO)=O.[S:26]([O-:29])([O-])=[O:27].[Na+].[Na+]>C(Cl)(Cl)Cl>[CH3:16][S:26]([C:3]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[CH:9]=2)[S:5][N:4]=1)(=[O:29])=[O:27]

Participants

5

Reactant 3

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 23086904HCID 23086904, compound

Product 1

HCID 23086897HCID 23086897, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In 8 ml of chloroform, 360 mg of 3-methylthio-5-(3-fluorophenyl)-1,2,4-thiadiazole was dissolved, to the resulting solution was added 982 mg of 3-chloroperoxybenzoic acid (65%<) with ice-cooling, and the mixture was stirred at room temperature for 7 hours. The reaction mixture was poured into an aqueous sodium sulfite solution, and the layers were separated. The organic layer was washed with an aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and concentrated to obtain 520 mg of 3-methylsulfonyl-5-(3-fluorophenyl)-1,2,4-thiadiazole.

Workup

  1. temperaturecooling
  2. customthe layers were separated
  3. washThe organic layer was washed with an aqueous sodium bicarbonate solution
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-f382648638ba4400bd9cda843f805560
Source dataset
uspto-grants-2008_04
Patent number
US07361675B2

Reaction notes

Loading…