Sodium Sulfite → HCID 23086908, compound

HRID 900842Notes

Reaction equation

HRID 900842 reaction equation
CS[C:3]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)[S:5][N:4]=1.Cl[C:16]1C=C(C=CC=1)C(OO)=O.[S:26]([O-:29])([O-])=[O:27].[Na+].[Na+]>C(Cl)(Cl)Cl>[CH3:16][S:26]([C:3]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)[S:5][N:4]=1)(=[O:29])=[O:27]

Participants

5

Reactant 3

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 23086891HCID 23086891, compound

Product 1

HCID 23086908HCID 23086908, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In 12 ml of chloroform, 1.5 g of 3-methylthio-5-(3-chlorophenyl)-1,2,4-thiadiazole was dissolved, to the resulting solution was slowly added 5.85 g of 3-chloroperoxybenzoic acid (65%<) with ice-cooling, and the mixture was stirred for 30 minutes with ice-cooling, and at room temperature for 2 hours. The reaction mixture was poured into an aqueous sodium sulfite solution, and the layers were separated. The organic layer was washed with an aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and concentrated to obtain 1.44 g of 3-methylsulfonyl-5-(3-chlorophenyl)-1,2,4-thiadiazole.

Workup

  1. temperaturecooling
  2. temperaturecooling
  3. waitat room temperature for 2 hours
  4. customthe layers were separated
  5. washThe organic layer was washed with an aqueous sodium bicarbonate solution
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-745bed674939484caadeec6cf82ae0ed
Source dataset
uspto-grants-2008_04
Patent number
US07361675B2

Reaction notes

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