Bromoacetic Acid → HCID 59698867, compound

HRID 901035Notes

Reaction equation

HRID 901035 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15](=[O:22])[N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[N:13]=2)=[O:7])=[CH:4][CH:3]=1.[Br:25][CH2:26][C:27](O)=[O:28]>C1COCC1>[Br:25][CH2:26][C:27]([N:19]1[CH2:18][CH2:17][N:16]([C:15](=[O:22])[CH2:14][C:12]2[N:13]=[C:9]([NH:8][C:6](=[O:7])[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:24][CH:23]=3)[S:10][CH:11]=2)[CH2:21][CH2:20]1)=[O:28]

Participants

4

Reactant 2

HCID 6227Bromoacetic AcidHCID 59698846HCID 59698846, compound

Product 1

HCID 59698867HCID 59698867, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

55.1 Using general method A, with THF instead of DMF as solvent, 4-chloro-N-[4-(2-oxo-2-piperazin-1-yl-ethyl)-thiazol-2-yl]-benzamide (example 54.2) was coupled with bromoacetic acid to give N-(4-{2-[4-(2-bromo-acetyl)-piperazin-1-yl]-2-oxo-ethyl}-thiazol-2-yl)-4-chloro-benzamide. Amorphous white solid.

Sources & evidence

ORD record
ord-ec79e558534e4c7d9b6c1751cefe9a95
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

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