反应详情

A mixture of 4-chloropyridine hydrochloride salt (15.0 g) and 2-methylaminoethanol (30 mL) was refluxed for 48 hour. After cooling to rt the crude mixture was added slowly to saturated solution of sodium bicarbonate (150 mL). The product was extracted with EtOAc (3×100 mL), the combined EtOAc was washed with brine (50 mL), dried (Na2SO4) and removed in vacuo to give the desired product 2-[methyl(pyridin-4-yl)amino]ethanol as yellow solid (7.0 g).

1. temperaturewas refluxed for 48 hour
2. extractionThe product was extracted with EtOAc (3×100 mL)
3. washthe combined EtOAc was washed with brine (50 mL)
4. dry with materialdried (Na2SO4)
5. customremoved in vacuo