Magnesium Hydroxide → HCID 69205773, compound

HRID 901850Notes

Reaction equation

[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH:18]([O:22][CH2:23][CH3:24])[C:19]([OH:21])=[O:20])=[CH:13][CH:12]=2)[C:3]2[CH:25]=[CH:26][CH:27]=[CH:28][C:2]1=2.[OH-].[Mg+2:30].[OH-]>>[Mg+2:30].[CH2:23]([O:22][CH:18]([CH2:17][C:14]1[CH:13]=[CH:12][C:11]([NH:10][CH2:9][CH2:8][CH2:7][N:4]2[CH2:5][CH2:6][O:1][C:2]3[CH:28]=[CH:27][CH:26]=[CH:25][C:3]2=3)=[CH:16][CH:15]=1)[C:19]([O-:21])=[O:20])[CH3:24].[CH2:23]([O:22][CH:18]([CH2:17][C:14]1[CH:13]=[CH:12][C:11]([NH:10][CH2:9][CH2:8][CH2:7][N:4]2[CH2:5][CH2:6][O:1][C:2]3[CH:28]=[CH:27][CH:26]=[CH:25][C:3]2=3)=[CH:16][CH:15]=1)[C:19]([O-:21])=[O:20])[CH3:24]

Participants

Reactant 2

HCID 73981Magnesium Hydroxide

HCID 10271353HCID 10271353, compound

Product 1

HCID 69205773HCID 69205773, compound

Conditions

Temperature: 50 °C

Procedure

A mixture of methanolic solution (2 ml) of 2-ethoxy-3-[4-{3-(3,4-dihydro-2H-benzo[b][1,4]oxazin-4-yl)propylamino}phenyl]propanoic acid (75 mg, 1 eq, 0.19 mmol) obtained in example 2 and magnesium hydroxide (5.6 mg, 0.5 eq, 0.095 mmol) was heated at 50° C. for 5 h. The resulting solution was condensed, azeotroped with benzene and then finally dried on high vacuum pump to obtain the title compound as freed flowing solid (100% yield, mp: 132-134° C.).

Workup

customcondensed
customazeotroped with benzene
customfinally dried on high vacuum pump

Sources & evidence

ORD record: ord-0cf191830dec4f58b9d3731e9279f936
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07365064B2

Reaction notes

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