Hydrochloric Acid → HCID 86614230, compound

HRID 902049Notes

Reaction equation

HRID 902049 reaction equation
[O:1]=[C:2]([O:23][CH2:24][CH:25]=[CH2:26])[CH2:3][O:4][NH:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1.[ClH:27]>C(OCC)(=O)C>[ClH:27].[ClH:27].[NH:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]([NH:5][O:4][CH2:3][C:2]([O:23][CH2:24][CH:25]=[CH2:26])=[O:1])[CH2:7][NH:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86614232HCID 86614232, compound

Product 1

HCID 86614230HCID 86614230, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

The 6.16 g of the product obtained in stage C are dissolved in 22 ml of ethyl acetate, and then 38 ml of a 4.3M solution of hydrogen chloride gas in ethyl acetate are added at 0° C. with stirring and under argon. The mixture is brought back to ambient temperature. After 30 min, the precipitate is filtered off, washed with ether and dried under reduced pressure. 5.63 g of the expected product (99%) are isolated.

Workup

  1. customis brought back to ambient temperature
  2. filtrationthe precipitate is filtered off
  3. washwashed with ether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-52f6c2e9c8c74c99b61693c428240164
Source dataset
uspto-grants-2008_04
Patent number
US07365071B2

Reaction notes

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