HCID 69221301, compound → HCID 69220293, compound

HRID 902051Notes

Reaction equation

HRID 902051 reaction equation
[O:1]=[C:2]1[N:8]([O:9][CH2:10][CH:11]=[CH2:12])[CH:7]2[CH2:13][N:3]1[N:4]([CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=12>C(Cl)Cl.FC(F)(F)C(O)=O>[O:1]=[C:2]1[N:8]([O:9][CH2:10][CH:11]=[CH2:12])[CH:7]2[CH2:13][N:3]1[N:4]([CH2:18][C:19]([OH:21])=[O:20])[C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=12

Participants

4

Reactant 1

HCID 69221301HCID 69221301, compound

Product 1

HCID 69220293HCID 69220293, compoundYield 41%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

The ester obtained in Example 24 is dissolved in 2.5 cm3 of CH2Cl2 and 7.5 cm3 of trifluoroacetic acid. After 15 min, the solvent is evaporated by entraining it with toluene, and then the compound is crystallized from ether. 519 mg of the expected acid (41%) are obtained.

Workup

  1. customthe solvent is evaporated
  2. customthe compound is crystallized from ether

Sources & evidence

ORD record
ord-41fd25aeaeb142e29e1665fa871facab
Source dataset
uspto-grants-2008_04
Patent number
US07365071B2

Reaction notes

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