HCID 11431603, compound → HCID 69316333, compound

HRID 902095Notes

Reaction equation

HRID 902095 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[C:11]1[CH:12]=[C:13]2[N:21]3[C:16](=[CH:17][C:18]([CH3:22])=[N:19][C:20]=13)[N:15]([CH:23]([CH2:27][CH2:28][CH3:29])[CH2:24][CH2:25][CH3:26])[C:14]2=[N:30][CH3:31].[ClH:32].C(OCC)(=O)C>C(OCC)(=O)C.C(O)C>[ClH:32].[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:9])[CH3:10])[CH:5]=[CH:4][C:3]=1[C:11]1[CH:12]=[C:13]2[N:21]3[C:16](=[CH:17][C:18]([CH3:22])=[N:19][C:20]=13)[N:15]([CH:23]([CH2:27][CH2:28][CH3:29])[CH2:24][CH2:25][CH3:26])[C:14]2=[N:30][CH3:31]

Participants

5

Reactant 2

HCID 11431603HCID 11431603, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 69316333HCID 69316333, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a suspension of [4-(2-bromo-4-isopropyl-phenyl)-6-methyl-1-(1-propyl-butyl)-1H-1,5,7b-triaza-cyclopenta[cd]inden-2-ylidene]-methyl-amine (135 mg) in a mixture of ethyl acetate (1.5 mL) and ethanol (0.2 mL) was added 4M HCl/ethyl acetate (0.25 mL) and concentrated under reduced pressure. The residue was solidified from Et2O to provide the title compound as an amorphous (73 mg).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-5242085275ae4c6c8a16192906bf8391
Source dataset
uspto-grants-2008_04
Patent number
US07365078B2

Reaction notes

Loading…