Hydrochloric Acid → HCID 68853764, compound

HRID 902260Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([CH:15]([C:30]3([OH:36])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[CH2:16][N:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[ClH:37]>>[ClH:37].[ClH:37].[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[CH:11][C:12]([CH:15]([C:30]3([OH:36])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[CH2:16][N:17]3[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]3)=[CH:13][CH:14]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68855806HCID 68855806, compound

Product 1

HCID 68853764HCID 68853764, compound

Procedure

In an analogous manner to Example 135, step 4, 1-[1-(3′-cyano-111′-biphenyl-4-yl)-2-piperazin-1-ylethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[2-(3′-cyano-1,1′-biphenyl-4-yl)-2-(1-hydroxycyclohexyl)ethyl]piperazine-1-carboxylate. MS (ES) m/z 390.3 ([M+H]+); HRMS: calcd for C25H31N3O.2.00 HCl, 461.2001; found (ESI), 390.2532.

Sources & evidence

ORD record: ord-1c01c1ecae8e48f38444100a11628d4f
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07365076B2

Reaction notes

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