Dimethylformamide dimethyl acetal → HCID 69267448, compound

HRID 902429Notes

Reaction equation

HRID 902429 reaction equation
[NH2:1][C:2]1[C:3]([C:22]#[N:23])=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[C:7]([O:20][CH3:21])[CH:6]=2.CO[CH:26](OC)[N:27]([CH3:29])[CH3:28]>C1(C)C=CC=CC=1>[CH2:13]([O:12][C:8]1[CH:9]=[C:10]2[C:5]([CH:4]=[C:3]([C:22]#[N:23])[C:2]([N:1]=[CH:26][N:27]([CH3:29])[CH3:28])=[CH:11]2)=[CH:6][C:7]=1[O:20][CH3:21])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 69269121HCID 69269121, compound

Product 1

HCID 69267448HCID 69267448, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 0.12 g (1.7 mmol) of 3-amino-6-benzyloxy-7-methoxynaphthalene-2-carbonitrile and 0.5 mL of N,N-dimethylformamide dimethyl acetal in 2.0 mL of toluene is heated under reflux for 4 hours. The solvent is evaporated and the residue is dried on high vacuum to yield N′-(7-benzyloxy-3-cyano-6-methoxynaphthalen-2-yl)-N,N-dimethylformamidine as an off-white solid.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 4 hours
  3. customThe solvent is evaporated
  4. customthe residue is dried on high vacuum

Sources & evidence

ORD record
ord-b7c69addf3f44de99ad4258929e0b6a1
Source dataset
uspto-grants-2008_04
Patent number
US07365197B2

Reaction notes

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